WebObjective: The TOPCAT trial is designed to evaluate the effect of spironolactone, an aldosterone antagonist, on morbidity, mortality, and quality of life in patients with HF-PEF. … Web2. mar 2024 · Die TOPCAT-Studie (Spironolacton versus Placebo) hat zwar den primären Endpunkt (kardialer Tod oder HIH) verfehlt, ihre Daten haben jedoch darauf hingewiesen, dass Spironolacton das Auftreten von HIH verhindern könnte. 10 Es gibt jedoch in den europäischen Leitlinien zur Behandlung der Herzinsuffizienz keine Empfehlung für den …
Clinical Phenogroups in Heart Failure With Preserved Ejection …
WebSupplementary Appendix This appendix has been provided by the authors to give readers additional information about their work. Supplement to: Pitt B, Pfeffer MA, Assmann SF, et … Web16. nov 2024 · TOPCAT study design and objectives. The design of the TOPCAT study has been described in detail previously. 10 Briefly, TOPCAT was a multi-centre, international, randomized, double blinded, placebo-controlled trial of spironolactone in adults with HFpEF recruited from over 270 clinical sites. The trial was funded by the National Heart, Lung ... flushing cosmetics guatemala
TOPCAT Study Shows Spironolactone Did Not Reduce Serious …
Web20. feb 2024 · The TOPCAT trial evaluated the effectiveness of aldosterone antagonist therapy in reducing cardiovascular mortality, aborted cardiac arrest, and heart failure … Web24. jún 2024 · Spironolactone did not demonstrate benefit with respect to the primary composite endpoint in the global TOPCAT (Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist) trial in patients with chronic heart failure with preserved ejection fraction (HFpEF). Web4. apr 2024 · Taken together with other reported regional differences in the TOPCAT trial, the results of the current study arouse concerns regarding study conduct at some sites in Russia and, by implication, Georgia, where event rates and responses to spironolactone were also of concern (Table S3 in the Supplementary Appendix). 2 Our findings suggest that ... green flowers hillcrest