WebSpleen Focus-Forming Viruses Strains of MURINE LEUKEMIA VIRUS that are replication-defective and rapidly transforming. The envelope gene plays an essential role in initiating … WebStrains of MURINE LEUKEMIA VIRUS that are replication-defective and rapidly transforming. The envelope gene plays an essential role in initiating erythroleukemia (LEUKEMIA, ERYTHROBLASTIC, ACUTE), manifested by splenic foci, SPLENOMEGALY, and POLYCYTHEMIA. Spleen focus-forming viruses are generated by recombination with …
Defective Friend Spleen Focus-Forming Virus: Interfering …
WebFriend strain of spleen focus-forming virus: a recombinant between mouse type C ecotropic viral sequences and sequences related to xenotropic virus. J Virol. 1977 May; 22 (2):361–372. [Europe PMC free article] [Google Scholar] Troxler DH, Lowy D, Howk R, Young H, Scolnick EM. Friend strain of spleen focus-forming virus is a recombinant ... WebThe virus recovered from the transfection assays can induce erythroblastosis, splenic foci, and polycythemia in infected mice. Fibroblast cultures transfected with the SFFV DNA … olearys haninge
Ivermectin Inhibits the Replication of Usutu Virus In Vitro
WebA series of insertion-deletion mutants was constructed in a molecularly cloned DNA copy of the Friend strain of spleen focus-forming virus (SFFV). The mutants were produced by inserting a synthetic oligonucleotide linker containing the recognition sequence of SalI endonuclease into several different locations of the SFFV DNA. Web1 Jun 1988 · Friend spleen focus-forming virus (F-SFFV) encodes a glycoprotein designated gp52, which is defective in its intracellular transport and accumulates in the rough endoplasmic reticulum. Only 3–5% of the mature form of gp52 eventually reaches the cell surface. Compared to transport-competent murine leukemia virus (MuLV) glycoproteins, … WebAbstract. The Friend spleen focus-forming virus has been a valuable tool for understanding the molecular events involved in the multiple stages of leukaemia. As summarized in … olearys gränby centrum