WebPAOLA-1 is the first and only phase 3 trial to investigate a PARP inhibitor combination regimen against an active and established maintenance therapy: bevacizumab 1-5 In … WebMay 28, 2024 · Conclusions: In the PAOLA-1 study, maintenance olaparib + bev provided a PFS and PFS2 benefit over pbo + bev in HRD+ pts, irrespective of FIGO stage and residual disease after upfront surgery. Clinical trial information: NCT02477644. PFS and PFS2 by FIGO stage in HRD+ pts in PAOLA-1. NE, not estimable.
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WebSep 17, 2024 · More and more patients with epithelial ovarian cancer will receive a PARP inhibitor as upfront therapy following positive results in the SOLO1, PAOLA-1 and the PRIMA/ENGOT-OV26/GOG-3012 studies in which olaparib prolonged the time to recurrence in BRCA1/2-mutated disease and niraparib prolonged progression-free … WebIn contrast, the subgroup analyses of the PAOLA-1 study showed that maintenance therapy with bevacizumab and olaparib resulted in a median improvement in the PFS of 19.5 months in the patients with HRD-positive tumors (including somatic BRCA1/2 mutations) compared with the placebo-controlled group. download big bang theory free
What’s next for PARP inhibitors? - Nature
WebJun 19, 2024 · For example, the ongoing phase III PAOLA-1 study, is testing the combination of olaparib and bevacizumab (Avastin) as a first-line maintenance treatment for patients with advanced, stage... WebJul 9, 2014 · Olaparib in gBRCA Mutated Pancreatic Cancer Whose Disease Has Not Progressed on First Line Platinum-Based Chemotherapy (POLO) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. WebSep 9, 2024 · Two studies report long-term survival benefits with olaparib in ovarian cancer. The PARP inhibitor shows durable clinical benefits in HRD+ patients with advanced disease reinforcing the importance of testing for BRCA mutations and/or HRD status. Positive long-term data from two phase III trials of olaparib maintenance treatment in … download big ben chimes