WebSep 30, 2008 · Each member of the dynamin family is involved in the division or fusion of a distinct eukaryotic membrane system. To gain insight into the kind of ancestral dynamin protein and eukaryotic membrane activity that evolved to regulate chloroplast division, we investigated the functions of the dynamin proteins that are most closely related to ... WebDynamin is a protein required for vesicle formation during synaptic vesicle endocytosis (SVE) and for clathrin-mediated endocytosis. It is part of a family of large guanosine triphosphatases (GTPases), including classical dynamins, dynamin-like protein, optic atrophy 1 (OPA1), and mitofusin. Dynamin readily self-assembles into rings and helices ...
UniProt
WebThe dynamin family of large GTPases has been implicated in vesicle formation from both the plasma membrane and various intracellular membrane compartments. The dynamin-like protein DLP1, recently identified in mammalian tissues, has been shown to be more closely related to the yeast dynamin proteins … WebOct 26, 2024 · Guanylate-binding proteins (GBPs) were originally identified as proteins induced by IFN-γ in human fibroblasts. 1 These proteins belong to the superfamily of large GTPases related to dynamin and ... loblaws mcarthur hours
Dynamin, a membrane-remodelling GTPase - PubMed
WebJan 11, 2012 · Dynamin, the founding member of a family of dynamin-like proteins (DLPs) implicated in membrane remodelling, has a critical role in endocytic membrane fission events. The use of complementary approaches, including live-cell imaging, cell-free studies, X-ray crystallography and genetic studies in mic … WebFeb 1, 2024 · Dynamin is a GTPase that plays a vital role in clathrin-dependent endocytosis and other vesicular trafficking processes by acting as a pair of molecular scissors for newly formed vesicles originating from … Dynamin is a GTPase responsible for endocytosis in the eukaryotic cell. Dynamin is part of the "dynamin superfamily", which includes classical dynamins, dynamin-like proteins, Mx proteins, OPA1, mitofusins, and GBPs. Members of the dynamin family are principally involved in the scission of newly formed vesicles … See more Dynamin itself is a 96 kDa enzyme, and was first isolated when researchers were attempting to isolate new microtubule-based motors from the bovine brain. Dynamin has been extensively studied in the context of See more During clathrin-mediated endocytosis, the cell membrane invaginates to form a budding vesicle. Dynamin binds to and assembles around the neck of the endocytic vesicle, … See more Small molecule inhibitors of dynamin activity have been developed, including Dynasore and photoswitchable derivatives (Dynazo) for spatiotemporal control of endocytosis with light (photopharmacology). See more In mammals, three different dynamin genes have been identified with key sequence differences in their Pleckstrin homology domains … See more Mutations in Dynamin II have been found to cause dominant intermediate Charcot-Marie-Tooth disease. Epileptic encephalopathy–causing de novo mutations in … See more • Dynamins at the U.S. National Library of Medicine Medical Subject Headings (MeSH) See more loblaws membership