2024 Chondrocyte subtype

Chondrocyte subtype

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August undefined, 2024

The number of chondrocyte cells created and their maturation process can be influenced by multiple different genes and proteins. Two proteins, bone morphogenetic protein 4(BMP-4) and fibroblast growth factor 2(FGF2) have been seen to influence the amount of differentiation into chondrocytes. Both proteins are known to play a role in embryonic stem cell differentiation into mesodermal cells, through signaling with BMP-4 and as FGF2 acting as a stimulator. From the … WebMar 1, 1995 · Calcium pyrophosphate-deposition disease (CPDD), also called {open_quotes}chondrocalcinosis{close_quotes} or {open_quotes}pseudogout{close_quotes}, is a disorder characterized by the deposition of calcium-containing crystals in joint tissue, which leads to arthritis-like symptoms.

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WebMay 20, 2024 · Results We identified and localized cell types in inner and outer meniscus, found new chondrocyte subtypes contributing to degeneration, and revealed how cellular compositions, functions, and interactions participated in degeneration. WebAug 16, 2024 · The chondrocyte subclusters were classified based on their potential regulatory, homeostatic, and effector functions in extracellular matrix (ECM) homeostasis. shiny goomy pokemon violet

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WebAs expected, all chondrocyte subtypes showed significant enrichment for the ontology terms 'cartilage development' and 'ECM organization' ( Figure 4 A). However, many of the cartilage ECM genes ... WebJul 2, 2024 · However, genes identified as potential mediators of chondrocyte phenotypes in OA that were exclusively expressed (in > 1%) by synoviocytes but not by any of the chondrocyte subtypes are indicated by red solid dots with arrows; among these were genes for several key pro-inflammatory cytokines implicated in the pathogenesis of OA, … WebSubchondral insufficiency fracture of the knee (SIFK) is a common cause of knee joint pain that mainly afflicts the elderly. Until now, how a sudden insufficiency fracture of subchondral bone affects the transcriptomic profiles of cartilage in SIFK and OA patients are largely unknown. Methods shiny goppie loomian legacy

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WebJun 10, 2024 · Single-Cell RNA-Seq Reveals Transcriptomic Heterogeneity and Post-Traumatic Osteoarthritis-Associated Early Molecular Changes in Mouse Articular Chondrocytes. Aimy Sebastian Lawrence Livermore National Laboratory, Physical and Life Science Directorate, Livermore, CA 94550, USA. Author profile Search articles by ORCID WebApr 11, 2024 · HIGHLIGHTS who: Veronica Panichi and collaborators from the Laboratorio di Immunoreumatologia e Rigenerazione Tissutale, Laboratorio di Patologia delle Infezioni Associate all`Impianto, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy have published the … Notch1: a novel player in the molecular crosstalk underlying articular chondrocyte … shiny gother anime adventureWebMechanical stress protects against chondrocyte pyroptosis through lipoxin A 4 via synovial macrophage M2 subtype polarization in an osteoarthritis model. Our previous study … shiny goppie

"WebDec 22, 2024 · Results We identified and localized cell types in inner and outer meniscus and found new chondrocyte subtypes associated with degeneration. The observations suggested understandings on how ... " - Chondrocyte subtype

Chondrocyte subtype

Single-Cell RNA Sequencing of the Nucleus Pulposus Reveals Chondrocyte …

WebJan 6, 2024 · Using single-cell RNAseq (scRNA-seq) data from adult mouse knee joint cartilage, we also determined that mature chondrocytes robustly express Loxl2, Loxl3, and Plod2, whereas Lox expression was more restricted to immature chondrocytes/mesenchymal progenitors ( Figure S3B ). WebFeb 21, 2024 · Chondrocytes, which make up the majority of the cells in all samples, are further split into three empirically defined populations: cartilage progenitor cells (CPCs), fibrochondrocyte progenitors (FCPs), and homeostatic chondrocytes (HomCs), as well as four new populations known as C1–4 ( Figures 1D,F ).

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WebFeb 21, 2024 · Characterization of Chondrocyte Subtypes. Chondrocytes secrete ECM such as collagen and proteoglycan, which are required for the NP’s structure and … WebOct 11, 2011 · Cartilage is a unique tissue characterized by an abundant extracellular matrix (ECM) 1 and a single cell type, the chondrocyte. However, the permanent hyaline cartilage, which provides the articulating surfaces of long bones and vertebrae, and the transient growth plate cartilage responsible for endochondral bone growth are uniform in neither …

WebAug 16, 2024 · The chondrocyte subclusters were classified based on their potential regulatory, homeostatic, and effector functions in extracellular matrix (ECM) homeostasis. Notably, in the NP, a PROCR +... Metrics - Spatially defined single-cell transcriptional profiling characterizes ... WebElucidating the molecular and functional profiles of various chondrocyte subtypes and understanding the interplay between these chondrocyte subtypes and other cell types in the joint will greatly ...

WebApr 10, 2024 · Autologous chondrocyte implantation (ACI) involves taking cartilage cells arthroscopically from a non-weight-bearing area of the knee: the cells are then cultured in a laboratory and multiplied, with the cells then being re-implanted into the chondral defect (Figure 1) in the knee 4–6 weeks later, most commonly as an open procedure.The … WebNov 18, 2024 · Chondrocytes were seeded on the inner side of the membrane (inner bottom group) to prevent direct contact with host cells, while soluble factors were …

WebApr 4, 2024 · The cellular communication among chondrocyte subtypes mediated by signaling pathways, such as PTN, VISFATIN, SPP1, and TGF-β, was selectively …

WebMar 9, 2024 · Chondrocyte inflammation and pyroptosis have been shown to play important roles in osteoarthritis (OA). In this study, we investigated the effects of exercise-induced irisin during different intensities of treadmill exercise in a rat OA model and the anti-inflammatory and antipyroptosis mechanism of irisin in OA chondrocytes. shiny goro shiny gorillaWebApr 12, 2024 · 例文. These cells lack the hematopoietic surface markers but express mesenchymal markers. これらの細胞は、造血表面マーカーを欠いていますが、間葉系マーカーを発現しています。. 例文. For example, mesenchymal subtypes were usually defined by the overexpression of mesenchymal markers and underexpression ... shiny gorebyssWebJun 10, 2024 · We identified six mouse chondrocyte subtypes with highly molecular fidelity to the human subtypes. This study allowed us to elucidate the full extent of … shiny gothweyWebJun 10, 2024 · We identified six mouse chondrocyte subtypes with highly molecular fidelity to the human subtypes. This study allowed us to elucidate the full extent of … shiny gossifleurWebHypertrophic chondrocytes orchestrate endochondral ossification by regulating osteogenic-angiogenic and osteogenic-osteoclastic coupling through the production of vascular endothelial growth factor (VEGF), receptor activator of nuclear factor kappa-B ligand (RANKL) and matrix metallopeptidases-9/13 (MMP-9/13). shiny gowther anime adventuresWebMay 10, 2024 · Although studies have reported that three subtypes, including pre-hypertrophic chondrocytes, hypertrophic chondrocytes, and proliferative chondrocytes exist in the ... Prein et al., 2016), new … shiny gothita pogo